This gene encodes a member of the ADAM a disintegrin and metalloprotease domain family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.
ADAM Metallopeptidase Domain 22
Last week, Adam Grandmaison—aka Adam22, the founder of the influential hip-hop podcast and video series No Jumper—took to Twitter to issue a blanket denial that he had ever sexually or physically assaulted any women. His statement came after anonymous allegations of sexual misconduct and physical abuse had been circulating on the social-media platform. Pitchfork has now spoken to two women who gave their accounts of alleged sexual assault and other misconduct by Grandmaison. He declined to comment for this story at the request of his lawyer. In a series of emails and over the phone, she detailed her story, which began when she first met Grandmaison in
Adam John Grandmaison born November 24, , best known as Adam22 , is an American podcaster, journalist, internet personality, rapper, and record executive. He is best known for being the creator and host of pop culture oriented podcast No Jumper. Grandmaison became a BMX rider at a young age and joined a group called "Jumper" which later would become known as "No Jumper". No Jumper is also the name of Grandmaison's podcast and brand that has now become his full time business. Grandmaison hosted the inaugural Trap Circus music festival in Miami , Florida in No Jumper was originally a blog on Tumblr, started by George Potter in and financed by Grandmaison. Revived in , Grandmaison's No Jumper podcast, hosted on YouTube, focuses on interviews with underground rap artists and tastemakers. His interview of Memphis rapper and well-known underground rap figure Xavier Wulf soon turned viral within hip-hop communities, sparking Grandmaison's newfound interest in interviewing known figures within both underground and mainstream hip-hop.
And of course, when it happens, no one the leaver or the faithful spouse could have predicted it. Am I that woman. I think the most important thing is to bring up the issues as questions rather than points as why she's wrong. Here are a few questions you could ask her. Will things get better. She was masterful at hiding the cuts and bruises with clothing. Try to find out his schedule in detail. Good advice for "newbie" docs and spouses. If you are both in high school, she may refuse altogether.